Introduction to CBD
The resinous glands of the Cannabis plant contain extraordinary molecules. These molecules have been found to provide corrective value and aid overall health and wellness. These molecules are known as cannabinoids, terpenoids and flavonoids. They are created in the plants trichrome during the flowering stage of the plant’s growth.
Any particular strain of Cannabis may contain up to 200 different terpenes and 113 known variants of Cannabinoids. These salubrious molecules are currently involved in numerous clinical trials around the world in order to investige their efficacy in treating a range of physiological and psychological issues such as chronic pain and systemic inflammation (a root factor in many diseases).
The Cannabinoids contained within these plants and its derivative products (extractions, concentrates, etc.) are divided into two categories, major and minor. The two most prominent and renowned are Tetrahydropcannabinol (THC) and Cannabidiol (CBD). Other major Cannabinoids include Cannabigerol (CBG), Cannabichromene (CBC) and Cannabidivarin (CBDV).
Cannabidiol (CBD) is one of the most remarkable compounds in the natural world. It was originally discovered in 1940 by Dr Roger Adams and his team at the University of Illinois. CBD has been found by numerous studies to be particularly beneficial to health with little to no side effects.
While CBD is widely touted to be ‘non-psychoactive’ this is an over simplification that defies the true definition of psychoactive. CBD in fact, delivers a benign psychotropic effect in comparison to its counterpart THC, most notably calming and relieving anxiety. While many cannot tolerate the mind-altering effects of THC, CBD offers none of the disadvantages of its stigma-laden cousin de Cannabis. People around the world can consume CBD void of the risk of becoming ‘high’ or ‘stoned.’
CBD is one of the few molecules manufactured outside of the human body that readily crosses the blood brain barrier. It’s half-life in humans is relatively long. It lasts approximately 3-5 days after oral dosing depending on factors such as weight and dosage.
How CBD works
CBD and other Cannabinoids interact with the human body via a network of microscopic cellular receptors. This is known as the endocannabinoid system (ECS). The ECS is present not only in humans, but in all mammals including dogs, cats and even fish. It is directly responsible for managing critical bodily functions such as appetite, mood, sleep, metabolism, inflammation and the ability to ward off infection or disease.
Scientists have identified the precise manner in which CBD molecules bind or dock with cellular receptors. The ECS is comprised of two primary receptor types CB1 and CB2. CB1 receptors are primarily located throughout the brain and central nervous system and feature at least two binding receptors to accommodate two or more Cannabinoid molecules. CB2 receptors are mainly found on white blood cells and in immune tissue. This may indicate they have an immunomodulatory role.
The process of CBD molecules binding with a CB1 receptor is known as allosteric modulation. This process limits the opportunities of THC and other endogenous Cannabinoids to stimulate the CB1 receptor. This in turn delivers a buffering effect to THC, decreasing its potency. Therefore proving useful in assisting consumers who may suffer anxiety when using Cannabis.
Today CBD is extracted from industrial hemp grown under licence. It is used as a food supplement to help improve and maintain health. You can find it in many forms such as oils, e-liquids, edibles, concentrates, capsules and many more ensuring any desired method of ingestion is catered for.